From CAR T-Cell Therapy to the Impact of Mentorship with Carl June, MD

Carl June, MD, Director of the PICI Center at the University of Pennsylvania, is a pioneer in immunotherapy whose groundbreaking work led to the first FDA-approved CAR T-cell therapy in 2017—redefining precision medicine and earning him the title of “the Father of CAR T-cell therapy.” Now, he continues to push the boundaries of cellular therapy, shaping the future of treatment.

In this episode of From Bench to Fireside, Dr. June joins PICI Chief Scientific Officer John Connolly, PhD, to discuss the next frontier of immunotherapy. From the power of collaboration in the PICI Network to cutting-edge advances in CRISPR and CAR T-cell delivery, they explore how these breakthroughs are accelerating patient impact. He also reflects on his legacy, the next generation of scientific visionaries, and why breaking down research silos is key to driving progress.

Dr. June was recently honored with the 2024 Breakthrough Prize in Life Sciences and the Warren Alpert Foundation Prize—and his story is featured in the PICI-produced documentary Of Medicine & Miracles (now streaming on Prime).

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